Categoria: Artigos
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19 ago 2023
>> Nicotine promotes e-cigarette vapour-induced lung inflammation and structural alterations
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Título do Estudo Nicotine promotes e-cigarette vapour-induced lung inflammation and structural alterations Fonte European Respiratory Journal 2023 61: 2200951; DOI: 10.1183/13993003.00951-2022 Justificativa O vapor do cigarro eletrônico está ganhando popularidade como uma alternativa ao tabagismo e pode induzir lesões pulmonares agudas. No entanto, o papel específico da nicotina no vapor do cigarro eletrônico […]
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12 ago 2023
>> Dose-Response Relationship between Obstructive Sleep Apnea Therapy Adherence and Healthcare Utilization
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Título do Estudo Dose-Response Relationship between Obstructive Sleep Apnea Therapy Adherence and Healthcare Utilization Fonte Malhotra A, Sterling KL, Cistulli PA, Pépin JL, Chen J, Woodford C, Alpert N, More S, Nunez CM, Benjafield AV. Dose-Response Relationship between Obstructive Sleep Apnea Therapy Adherence and Healthcare Utilization. Ann Am Thorac Soc. 2023 Jun;20(6):891-897. doi: 10.1513/AnnalsATS.202208-738OC. […]
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5 ago 2023
>> Newly diagnosed non-small cell lung cancer with interstitial lung abnormality: Prevalence, characteristics, and prognosis
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Título do Estudo Newly diagnosed non-small cell lung cancer with interstitial lung abnormality: Prevalence, characteristics, and prognosis Referência Zhu M, Yi J, Su Y, Zhang Y, Gao Y, Xu X, Zhang S, Zhang Y, Huang K. Newly diagnosed non-small cell lung cancer with interstitial lung abnormality: Prevalence, characteristics, and prognosis. Thorac Cancer. 2023 Jul;14(19):1874-1882. […]
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29 jul 2023
>> Airway-Occluding Mucus Plugs and Mortality in Patients With Chronic Obstructive Pulmonary Disease
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Título do Estudo Airway-Occluding Mucus Plugs and Mortality in Patients With Chronic Obstructive Pulmonary Disease Autores Alejandro A. Diaz, MD, MPH1,2; José L. Orejas, MD1,2; Scott Grumley, MD3; et al Hrudaya P. Nath, MD3; Wei Wang, PhD2,4; Wojciech R. Dolliver, MD1; Andrew Yen, MD5; Seth J. Kligerman, MD5,6; Kathleen Jacobs, MD5; Padma P. Manapragada, MD3; Mostafa Abozeed, MD, MSc, PhD3; Muhammad Usman Aziz, MD3; Mohd Zahid, MD3; Asmaa N. Ahmed, MD, MBBCh, MSc3; Nina L. Terry, MD3; Ruben San José Estépar, MSc2,7; Victor Kim, MD8; Barry J. Make, MD9; MeiLan K. Han, MD10; Sushilkumar Sonavane, MD11; George R. Washko, MD, MSc1,2; Michael Cho, MD, MPH1,2,12; Raúl San José Estépar, PhD2,7 – Author Affiliations Fonte JAMA. 2023;329(21):1832-1839. doi:10.1001/jama.2023.2065. Resumo Tampões de muco nas […]
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22 jul 2023
>> Efficacy of Tezepelumab in Severe, Uncontrolled Asthma: Pooled Analysis of the PATHWAY and NAVIGATOR Clinical Trials
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Título do Estudo Efficacy of Tezepelumab in Severe, Uncontrolled Asthma: Pooled Analysis of the PATHWAY and NAVIGATOR Clinical Trials Fonte Am J Respir Crit Care Med. 2023 Jul 1;208(1):13-24. doi: 10.1164/rccm.202210-2005OC. Contexto Diversos imunobiológicos (omalizumabe, mepolizumabe, reslizumabe, benralizumabe e dupilumabe) apresentaram benefícios em pacientes com asma grave. Entretanto, estudos demonstraram eficácia limitada nos pacientes […]
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15 jul 2023
>> Endosonography With or Without Confirmatory Mediastinoscopy for Resectable Lung Cancer: A Randomized Clinical Trial
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Título do Estudo Endosonography With or Without Confirmatory Mediastinoscopy for Resectable Lung Cancer: A Randomized Clinical Trial Autores Jelle E. Bousema, MD1; Marcel G.W. Dijkgraaf, PhD2; Erik H.F.M. van der Heijden, MD, PhD3; Ad F.T.M. Verhagen, MD, PhD4; Jouke T. Annema, MD, PhD5; Frank J.C. van den Broek, MD, PhD6; on behalf of the […]
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8 jul 2023
>> Evaluation of local nasal immunotherapy to Dermatophagoides sp. in patients with allergic rhinitis
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Título do Estudo Evaluation of local nasal immunotherapy to Dermatophagoides sp. in patients with allergic rhinitis Fonte Original Article – Med Clinic Res, 2023-ISSN: 2577 – Werber-Bandeira L, et al. Justificativa A imunoterapia alérgeno específica (AIT) é considerada a terapêutica que modifica o curso natural da doença alérgica. Com relação ao uso pelo paciente, […]
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1 jul 2023
>> Overall Survival with Osimertinib in Resected EGFR-Mutated NSCLC
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Título do Estudo Overall Survival with Osimertinib in Resected EGFR-Mutated NSCLC Fonte Masahiro Tsuboi, M.D., et al. – June 4, 2023 DOI: 10.1056/NEJMoa2304594 Contexto Entre os pacientes com câncer de pulmão de não pequenas células (CPNPC) ressecado, com mutação no receptor do fator de crescimento epidérmico (EGFR), estágio IB a IIIA, o tratamento adjuvante com […]
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24 jun 2023
>> Endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy in the diagnosis of mediastinal lesions: safety, feasibility and diagnostic yield – experience in 50 cases
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Título do Estudo Endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy in the diagnosis of mediastinal lesions: safety, feasibility and diagnostic yield – experience in 50 cases Fonte Miguel Ariza-Prota , Javier Pérez-Pallarés, Alejandro Fernández-Fernández, Lucía García-Alfonso,Juan A. Cascón , Héctor Torres-Rivas , Luis Fernández-Fernández, Inmaculada Sánchez, Maria Gil,Marta García-Clemente and Francisco López-González. https://doi.org/10.1183/23120541.00448-2022 ERJ Open Res […]
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17 jun 2023
>> Efzofitimod for the Treatment of Pulmonary Sarcoidosis
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Título do Estudo Efzofitimod for the Treatment of Pulmonary Sarcoidosis Fonte Chest. 2023 Apr;163(4):881-890. Justificativa Os glicocorticoides são considerados a terapia de primeira linha no tratamento da sarcoidose, mas podem estar associadas a efeitos colaterais significativos. O receptor da neuropilina 2 participa da inflamação e formação da reação granulomatosa na sarcoidose. O Efzofitimode […]